Cellular Calcium Information Server

This server provides access to the following calcium-binding protein related databases:

Protein Structure Atomic Coordinates

  • 1NWD   NMR structure of Ca2+-calmodulin bound to the dimeric C-terminal domain of Petunia glutamate decarboxylase
  • Yap, K.L., Yuan, T., Mal, T.K., Vogel, H.J. and Ikura, M. (2003) Structural basis for simultaneous binding of two carboxy-terminal peptides of plant glutamate decarboxylase to calmodulin. J. Mol. Biol. 328,193-204.

  • 1N4K   Crystal Structure Of The Inositol 1,4,5-Trisphosphate Receptor Binding Core In Complex With IP3
  • Bosanac, I., Alattia, J.R., Mal, T.K., Chan, J., Talarico, S., Tong, F.K., Tong, K.I., Yoshikawa, F., Furuichi, T., Iwai, M., Michikawa, T., Mikoshiba, K. and Ikura, M. (2002) Structure of the Inositol 1,4,5-Trisphosphate Receptor Binding Core in Complex with its Ligand. Nature 420, 696-700.

  • 1MYW   Crystal structure of a Yellow Fluorescent Protein With Improved Maturation and Reduced Environmental Sensitivity
  • Rekas, A., Alattia, J.R., Nagai, T., Miyawaki, A. and Ikura, M. (2002) Crystal structure of Venus, a Yellow Fluorescent Protein with Improved Maturation and Reduced Environmental Sensitivity. J. Biol. Chem. 277, 50573-50578.

  • 1IQ5   Crystal structure of Ca2+/Calmodulin-CaMKK peptide Complex
  • Kurokawa, H., Osawa, M., Kurihara, H., Katayama, N., Tokumitsu, H., Swindells, M.B., Kainosho, M. and Ikura, M. (2001) Target-Induced Conformational Adaptation of Calmodulin Revealed by the Crystal Structure of a Complex with Nematode Ca2+/Calmodulin-Dependent Kinase Kinase Peptide. J. Mol. Biol. 312, 59-68.

  • 1JOY   Homodimeric Domain of EnvZ
  • Tomomori, C., Tanaka, T., Dutta, R., Park, H., Saha, S.K., Zhu, Y., Ishima, R., Liu, D., Tong, K.I., Kurokawa, H., Qian, H., Inouye, M. and Ikura, M.  (1999) Solution Structure of the Homodimeric Domain of Escherichia Coli Histidine Kinase EnvZ.  Nat. Struct. Biol. 6, 729-734.

  • 1CKK   NMR structure of Ca2+/Calmodulin-CaMKK peptide Complex
  • Osawa, M., Tokumitsu, H., Swindells, M.B., Kurihara, H., Orita, M., Shibanuma, T., Furuya, T., and Ikura, M. (1999)  A Novel Target Recognition by Calmodulin Revealed by its Solution Structure in Complex with a Peptide Derived from Ca2+ Calmodulin Dependent Protein Kinase Kinase. Nature Struct. Biol. 6, 819-824.

  • 1JBA   Unmyristoylated GCAP-2
  • Ames, J.B., Dizhoor, A.M., Ikura, M., Palczewski, K., and Stryer, L. (1999)  Three-dimensional Structure of GCAP-2, a Calcium Sensitive Modulator of Photoreceptor Guanylyl Cyclases.  J. Biol. Chem. 274, 19329-19337.

  • 1BXD   Histidine Kinase Domain of EnvZ
  • Tanaka, T., Saha, S.K., Tomomori, C., Ishima, R., Liu, D., Tong, K.I., Park, H., Dutta, R., Qin, L., Swindells, M.B., Yamazaki, T., Ono, A.M., Kainosho, M., Inouye, M. and Ikura, M. (1998) NMR
    Structure of the Histidine Kinase Domain of the E. Coli Osmosensor EnvZ.  Nature 396, 88-92.

  • 1TBA   TBP-TAFII230 Complex
  • Liu, D., Ishima, R., Tong, K.I., Bagby, S., Kokubo, T., Muhandiram, D.R., Kay, L.E., Nakatani, Y. and Ikura, M. (1998)  Solution Structure of a TBP-TAFII230 Complex: Protein Mimicry of the Minor Groove Surface of the TATA Box Unwound by TBP.  Cell 94, 573-583.

  • 1MUX   Ca2+/Calmodulin-W-7 Complex
  • Osawa M., Swindells, M.B., Tanikawa, J., Tanaka, T., Mase, T., Furuya, T. and Ikura, M. (1998) Solution Structure of Calmodulin-W-7 complex: Basis of Diversity NMRin Molecular Recognition. J. Mol. Biol. 276, 165-176.

  • 1JSA   Calcium-bound Myristoylated Recoverin
  • Ames, J.B., Ishima, R., Tanaka, T., Gordon, J.I., Stryer, L. and Ikura, M. (1997) Molecular Mechanics of Calcium-Myristoyl Switches. Nature 389,198-202.

  • 1EDH   E-Cadherin Domains 1 & 2 in Complex with Calcium
  • Nagar, B., Overduin, M., Ikura, M. and Rini, J.M. (1996) Structural Basis of Calcium-induced E-Cadherin Rigidification and Dimerization. Nature 380, 360-364.

  • 1SUH   Amino-Terminal Domain of Epithelial Cadherin in the Calcium Bound State
  • Overduin, M., Tong, K.I., Kay, C.M. and Ikura, M. (1996) 1H, 15N and 13C Resonance Assignments and Monomeric Structure of the Amino-Terminal Extracellular Domain of Epithelial Cadherin. J. Biomol. NMR 7, 173-189.

  • 1TFB   Human General Transcription Factor TFIIB Core Domain
  • Bagby, S., Kim, S., Maldonado, E., Tong, K.I., Reinberg, D. and Ikura, M. (1995) The Solution Structure of the Carboxy-terminal Core Domain of Human TFIIB: Similarity to Cyclin A and Interaction with the TATA Binding Protein Cell 82, 857-867.

  • 1DMO   Calcium-free Calmodulin
  • Zhang, M., Tanaka, T. and Ikura, M. (1995) Solution Structure of Apocalmodulin: Conformational Transition Induced by Calcium Binding. Nat. Struct. Biol. 2, 758-767.

  • 1IKU   Myristoylated Recoverin in the Calcium-free State
  • Tanaka, T., Ames, J.B., Harvey, T.S., Stryer, L., Ikura, M. (1995) Sequestration of the Membrane-targetting Myristoyl Group of Recoverin in the Calcium-free State. Nature 376, 444-448.

  • 1PRS (30 structures) 1PRR (minimized average structure)   Development-Specific Protein S (Spore Coat Protein S)
  • Bagby, S., Harvey, T.S., Eagle, S.G., Inouye, S. and Ikura, M. (1994) NMR-Derived Three-Dimensional Solution Structure of Protein S Complexed with Calcium. Structure 2, 107-122.

  • 2BBN (21 structures) 2BBM (minimized average structure)   Calmodulin (Calcium-bound) Complexed with Rabbit Skeletal Myosin Light Chain Kinase (Calmodulin-binding Domain)
  • Ikura, M., Clore, G.M., Gronenborn, A.M., Zhu, G., Klee, C.B. and Bax, A. (1992) Solution Structure of a Calmodulin-target Peptide Complex by Multidimensional NMR. Science 256, 632.


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NMR Chemical Shifts

The following documents are made available for public use on condition that should they be used in your work, the author(s) of the documents will be acknowledged.


Link to source code

Yap KL, Ames JB, Swindells MB, Ikura M.
"Diversity of conformational states and changes within the EF-hand protein superfamily" Proteins. 1999 Nov 15;37(3):499-507.

Yap KL, Ames JB, Swindells MB, Ikura M.
"Vector geometry mapping. A method to characterize the conformation of helix-loop-helix calcium-binding proteins" Methods Mol Biol. 2002;173:317-24.