Research ProjectsThere are five research areas which our laboratory is interested in:
- Calcium Signaling
- Cell-cell Communication
- Gene Regulation
- Structure-based Ligand Discovery
- Structural Bioinformatics
- in vivo FRET Imaging
We are interested in proteins that are involved in calcium signaling, cell-cell communication and gene regulation. Our main focus is to determine the structure of these proteins by NMR or X-ray crystallography, in order to understand the mechanisms underlying their biological functions. We are also interested in utilising the structural information to design and synthesize recombinant proteins with new functions and ligands that can inhibit or enhance the biological activities. In addition, our recent interests include structural bioinformatics studies, mainly focusing on development of protein sequence/structure/function (SSF) databases and related software. Most recently, we have been engaging in vivo FRET imaging studies that enable us to visualize protein-protein interactions and protein comformational changes. More specific projects within these areas are described below.