Welcome to the Ikura Laboratory!
Dept. of Medical Biophysics, Faculty of Medicine, University of Toronto
Division of Signaling Biology, Ontario Cancer Institute
Our laboratory is interested in elucidating structure-function relationships of biological macromolecules. Of particular interest are proteins involved in calcium signalling, cell-cell interactions and transcriptional regulation (see research projects). Our primary tool is high-resolution NMR spectroscopy, but we also use a variety of biophysical and molecular biology techniques, including X-ray crystallography and in vivo FRET (fluorescence resonance energy transfer) imaging microscopy. Detailed structural analysis of proteins combined with characterization of proteins' biological functions offers not only a promising future for fundamental molecular biology, but also excellent platforms for drug discovery enterprise targeting various disease-linked gene products.
This site was created and maintained by: Le Zheng and Noboru Ishiyama (current), Fiona Bower (2008-2010), Alicja Podgorski (2006-2007), Tina Papadakos (2004 - 2006), Kyoko Yap (1997 - 2004) Jane Gooding (2000 - 2004) and Christine Bleka (2002-2003)