Selected Publications


Wyatt HD, Laister RC, Martin SR, Arrowsmith CH, West SC. The SMX DNA Repair Tri-nuclease, Mol Cell. 2017 Mar 2;65(5):848-860 (2017).

Stuckey JI, Dickson BM, Cheng N, Liu Y, Norris JL, Cholensky SH, Tempel W, Qin S, Huber KG, Sagum C, Black K, Li F, Huang XP, Roth BL, Baughman BM, Senisterra G, Pattenden SG, Vedadi M, Brown PJ, Bedford MT, Min J, Arrowsmith CH, James LI, Frye SV. A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1, Nat Chem Biol 12(3):180-7 (2016).

Zhu J, Sammons MA, Donahue G, Dou Z, Vedadi M, Getlik M, Barsyte-Lovejoy D, Al-awar R, Katona BW, Shilatifard A, Huang J, Hua X, Arrowsmith CH, Berger SL. Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth, Nature 525(7568):206-11 (2015).

Grebien F, Vedadi M, Getlik M, Giambruno R, Grover A, Avellino R, Skucha A, Vittori S, Kuznetsova E, Smil D, Barsyte-Lovejoy D, Li F, Poda G, Schapira M, Wu H, Dong A, Senisterra G, Stukalov A, Huber KV, Schönegger A, Marcellus R, Bilban M, Bock C, Brown PJ, Zuber J, Bennett KL, Al-Awar R, Delwel R, Nerlov C, Arrowsmith CH, Superti-Furga G. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia, Nat Chem Biol 11(10):815 (2015).

Edwards AM, Arrowsmith CH, Bountra C, Bunnage ME, Feldmann M, Knight JC, Patel DD, Prinos P, Taylor MD, Sundström M, ; SGC Open Source Target-Discovery Partnership Preclinical target validation using patient-derived cells, Nat Rev Drug Discov 14(3):149-50 (2015).

Tardat M, Albert M, Kunzmann R, Liu Z, Kaustov L, Thierry R, Duan S, Brykczynska U, Arrowsmith CH, Peters AH. Cbx2 Targets PRC1 to Constitutive Heterochromatin in Mouse Zygotes in a Parent-of-Origin-Dependent Manner. Mol Cell 58(1):157-71 (2015).

Shah MA, Denton EL, Arrowsmith CH, Lupien M, Schapira M. A global assessment of cancer genomic alterations in epigenetic mechanisms. Epigenetics Chromatin 7(1):29 (2014).

Dalia Barsyte-Lovejoy, Fengling Li, Menno J. Oudhoff, John Tatlock, Aiping Dong, Hong Zheng, Hong Wu, Spencer A. Freeman, Matthieu Schapira, Guillermo Senisterra, Ekaterina Kuznetsova, Abdellah Allali-Hassani, Paul Fish, Brian Gerstenberger, Lee Roberts, Caroline Benn, Rachel Grimely, Gingras, A.-C., Fabio M.V. Rossi, Peter J. Brown, Mark Bunnage, Dafydd Owen, Colby Zaph, Masoud Vedadi, Cheryl H. Arrowsmith. PFI-2, a Potent and Selective Inhibitor of SETD7 Methyltransferase Activity, Proc Natl Acad Sci, 111, 12853-8 (2014).

Kathy Ann Gelato, Maria Tauber, Michelle Ong, Stefan Winter, Kyoko Hiragami-Hamada, Julia Sindlinger, Alexander Lemak, Yvette Bultsma, Scott Houliston, Dirk Schwarzer, Nullin Divecha, Cheryl H. Arrowsmith, and Wolfgang Fischle. Accessibility of different histone H3-binding domains of UHRF1 is allosterically regulated by phosphatidylinositol 5-phosphate. Mol. Cell, 54:905-19 (2014)

Alexander Lemak, Bin Wu, Adelinda Yee, Scott Houliston, Hsiau-Wei Lee, Aleksandras Gutmanas , Xianyang Fang , Maite Garcia, Anthony Semesi, Yun-Xing Wang, James H. Prestegard and Cheryl H. Arrowsmith. Structural characterization of flexible two-domain protein in solution using Small Angle X-Ray Scattering and NMR data. Structure, 22, 1862-74 (2014).

Guillermo Senisterra, Hong Wu, Abdellah Allali Hassani, Gregory A Wasney, Dalia Barsyte-Lovejoy, Ludmila Dombrovsky, Aiping Dong, Kong T. Nguyen, David Smil, Yuri Bolshan, Taraneh Hajian, Hao He,Alma Seitova, Irene Chau, F Li, Gennadiy Poda, JF Couture, Peter J. Brown, Rima Al-awar, Matthieu Schapira, Cheryl H. Arrowsmith and Masoud Vedadi.Small molecule inhibition of MLL activity by disruption of its interaction with WDR5, Biochemical Journal 449:151-9 (2013)

James, Lindsey I.; Barsyte-Lovejoy, Dalia; Zhong, Nan; Krichevsky, Liubov; Korboukh, Victoria K.; Herold, J. Martin; MacNevin, Christopher J.; Norris, Jacqueline L.; Sagum, Cari C.; Tempel, Wofram; Marcon, Edyta; Guo, Hongbo; Gao, Cen; Huang, Xi-Ping; Shili Duan; Kireev, Dmitri B.; Jin, Jian; Greenblatt, Jack; Roth, Bryan; Janzen, William P.; Brown, Peter J.; Bedford, Mark T.; Arrowsmith, Cheryl H.; Frye, Stephen V.  Discovery of a chemical probe for a methyl-lysine reader domain: L3MBTL3, Nature Chem Biology 9, 184-91 (2013).

Scott B. Rothbart, Krzysztof Krajewski, Nataliya Nady, Wolfram Tempel, Sheng Xue, Aimee N. Iberg, Dalia Barsyte-Lovejoy, Jorge Y. Martinez, Mark T. Bedford, Stephen M. Fuchs, Cheryl H. Arrowsmith, and Brian D. Strahl. Association of UHRF1 with H3K9 methylation directs the maintenance of DNA methylation, Nature Struct Mol Biol 19, 1155-60 (2012)

Nataliya Nady, Liubov Krichevsky, Nan Zhang, Shili Duan, Maria F. Amaya, Wolfram Tempel, Mani Ravichandran, Cheryl H. Arrowsmith. Histone Substrate Recognition by Human Malignant Brain Tumor Domains, J Mol Biol, 423, 702-18 (2012)

Wenyu Yu, Emma J. Chory, Amy K. Wernimont, Alex Scopton, Alexander Federation, Jason J. Marineau, Jun Qi, Dalia Barsyte-Lovejoy, Joanna Yi, Richard Marcellus, Roxana E. Iacob, John R. Engen, Erno Wienholds, Fengling Li, Javier Pineda, Guillermina Estiu, Tatiana Shatseva, Taraneh Hajian, Rima Al-awar, John E. Dick, Masoud Vedadi, Peter J. Brown, Cheryl H. Arrowsmith*, James E. Bradner*, Matthieu Schapira*. Catalytic site remodeling of the DOT1L methyltransferase by selective inhibitors, Nature Comm. 3, 1288 (2012)

Lilia Kaustov, Hui Ouyang, Maria Amaya, Alexander Lemak, Nataliya Nady, Shili Duan, Greg Wasney, Masoud Vedadi, Matthieu Shapira, Jinrong Min & Cheryl Arrowsmith, Recognition and specificity determinants of the human Cbx chromodomains, J Biol Chem. 286, 521-9 (2011).

Alexander Lemak, Aleksandras Gutmanas, Seth Chitayat, Murthy Karra, Christophe Farès, Maria Sunnerhagen, Cheryl H. Arrowsmith, A novel strategy for NMR resonance assignment and protein structure determination, J Biomol NMR, 49, 27-38 (2011).

Natalie Nady, Alexander Lemak, John R. Walker, George V. Avvakumov, Michael S. Kareta, Mayada Achuor, Sheng Xue, Shili Duan, Abdellah Allali-Hassani, Frédéric Chédin, and Sirano Dhe-Paganon, Cheryl H.Arrowsmith. Recognition of Multivalent Histone States Associated with Heterochromatin by UHRF1 Protein J. Biol Chem 286, 24300-11 (2011).

Masoud Vedadi, Dalia Barsyte-Lovejoy, Feng Liu, Sylvie Rival-Gervier, Abdellah Allali-Hassani, Tim J. Wigle, Peter A. DiMaggio, Gregory A. Wasney, Alena Siarheyeva, Aiping Dong, Wolfram Tempel, Xin Chen, Irene Chau, Thomas J. Mangano, Jon M. Evans, Catherine D. Simpson, Samantha G. Pattenden, Jacqueline L. Norris, Dmitri B. Kireev, Ashutosh Tripathy, Aled Edwards, Bryan L. Roth, William P. Janzen, Benjamin A. Garcia, James Ellis, Peter J. Brown, Stephen V. Frye, Cheryl H. Arrowsmith*, Jian Jin*, A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells, Nature Chem. Biol. 7(8):566 (2011).

Schuetz A, Min J, Allali-Hassani A, Schapira M, Shuen M, Loppnau P, Mazitschek R, Kwiatkowski NP, Lewis TA, Maglathin RL, McLean TH, Bochkarev A, Plotnikov AN, Vedadi M, Arrowsmith CH. Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity. J. Biol. Chem. 283. 11355-63 (2008).

Nady N, Min J, Kareta MS, Chédin F, Arrowsmith CH, A SPOT on the chromatin landscape? Histone peptide arrays as a tool for epigenetic research. Trends Biochem Sci, 33:305-13 (2008).

Yi Sheng, R. Laister, A. Lemak, B. Wu, E. Tai, S. Duan, J. Lukin, M. Sunnerhagen, S. Srisailam, M. Karra, S. Benchimol, and CH Arrowsmith, Molecular Basis of Pirh2-mediated p53 ubiquitylation. Nat Struct Mol Biol, 15,1334-42 (2008).

George V. Avvakumov, John R. Walker, Sheng Xue, Yanjun Li, Shili Duan, Christian Bronner, Cheryl H. Arrowsmith, and Sirano Dhe-Paganon, Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1. Nature, 455; 822-5 (2008).

Jinrong Min, Abdellah Allali-Hassani, Nataliya Nady, Chao Qi, Hui Ouyang, Yongsong Liu, Farrell MacKenzie, Masoud Vedadi and Cheryl H Arrowsmith. L3MBTL1 recognition of mono- and dimethylated histones. Nat Struct Mol Biol. 14, 1229-30 (2007).

Sheng Y, Saridakis V. Sarkari F, Duan S, Wu T, Arrowsmith CH, and Frappier L. Molecular recognition of p53 and MDM2 by USP7/HAUSP, Nat Struct Mol Biol, 13, 285-91. (2006) Molecular recognition of p53 and MDM2 by USP7/HAUSP, Nat Struct Mol Biol, 13, 285-91. (2006).

Schuetz A, Allali-Hassani A, Martin F, Loppnau P, Vedadi M, Bochkarev A, Plotnikov AN, Arrowsmith CH, Min J. Structural basis for molecular recognition and presentation of histone H3 By WDR5. EMBO J Aug 31 (2006).

Saridakis V, Sheng Y, Sarkari F, Holowaty MN, Shire K, Nguyen T, Zhang RG, Liao J, Lee W, Edwards AM, Arrowsmith CH and Frappier L. Structure of the p53-binding domain of HAUSP/USP7 bound to Epstein-Barr Nuclear Antigen 1 Implications for EBV-mediated immortalization. Mol Cell. 18, 25-36. (2005).

E. Botchareva, L. Kaustov, A. Ayed, G-S. Yi, Y. Lu, A. Pineda-Lucena, J.C.C. Liao, A. Okorokov, J. Milner, C.H. Arrowsmith and A. Botcharev, Single stranded DNA mimicry in the p53 transactivation domain interaction with RPA. Proc Natl Acad Sci. 102, 15412-7.(2005).

Yee, A., Chang, X., Pineda-Lucena, A., Wu, B., Semesi, A., Le, B., Ramelot, T., Lee, G.M., Bhattacharyya, S., Gutierrez, P., Denisov, A., Lee, C.H., Cort, J.R., Kozlov, G., Liao, J., Finak, G., Chen, L., Wishart, D., Lee, W., McIntosh, L.P., Gehring, K., Kennedy, M.A., Edwards, A.M. and  Arrowsmith, C.H. An NMR approach to structural proteomics. PNAS 99, (4), 1825-30 (2002)

Christendat, D., Yee, A., Dharamsi, A., Kluger, Y., Savchenko, A., Cort, J.R., Booth, V., Mackereth, C.D., Saradakis, V., Ekiel, I., Kozlov, G., Maxwell, K.L., Wu, N., McIntosh, L.P., Gehring, K., Kennedy, M.A., Davison, A.R., Pai, E.F., Gerstein, M., Edwards, A.M. and Arrowsmith, C.H., Structural proteomics of an archeon, Nat. Struct. Biol. 7, (10), 903-909 (2000).