Cheryl Arrowsmith Lab

Welcome to the Arrowsmith Laboratory!

Our research focuses on the structural and biochemical characterization of proteins involved in cancer pathways, especially that of the tumor suppressor p53. The goals of our research are to understand how p53 and related proteins communicate and signal in complex processes such as DNA damage recognition and repair, transcription regulation, and ubiquitin-mediated degradation. We take a genome-wide approach, studying whole families of related proteins that may have an impact on these pathways in order to understand how proteins selectively interact with specific members of a sequence-related family. We use Nuclear Magnetic Resonance (NMR) spectroscopy and X-ray crystallography in conjunction with other physical and biochemical techniques to study the three-dimensional (3D) structure, dynamics and biochemical properties of proteins, protein-DNA, protein-peptide and protein-protein complexes.

Division of Molecular & Structural Biology, Ontario Cancer Institute

Department of Medical Biophysics, Faculty of Medicine, University of Toronto