Our laboratory is interested in elucidating structure-function relationships of biological macromolecules. Of particular interest are proteins involved in calcium signalling, cell-cell interactions and transcriptional regulation (see research projects). Our primary tool is high-resolution NMR spectroscopy, but we also use a variety of biophysical and molecular biology techniques, including X-ray crystallography and in vivo FRET (fluorescence resonance energy transfer) imaging microscopy. Detailed structural analysis of proteins combined with characterization of proteins' biological functions offers not only a promising future for fundamental molecular biology, but also excellent platforms for drug discovery enterprise targeting various disease-linked gene products.

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